Chaste Tree is used to support and treat acne, menstrual irregularities, premenstrual syndrome, mastalgia, menopause, and lactation. It is widely used throughout Europe; the German Commission E has approved its use for irregularities of the menstrual cycle, premenstrual disturbances, and breast pain. 

German studies show that the alcohol extract of the whole berry is more efficacious than isolates of individual constituents. The berry contains flavonoids including casticin, quercetagetin, isovitexin, essential oils, diterpenes, and glycosides. It’s the flavonoids that have been shown to affect estrogen receptors. 

Chaste Tree has many clinical trials showing its support of normal hormone levels, particularly progesterone and many studies show positive outcomes for conditions related to the female menstrual cycle. In menopause, a randomized controlled double-blind clinical trial showed that Chaste Tree can alleviate menopause symptoms, including anxiety and vasomotor symptoms.

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